1hoe
From Proteopedia
(New page: 200px<br /><applet load="1hoe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hoe, resolution 2.0Å" /> '''CRYSTAL STRUCTURE DET...) |
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| - | [[Image:1hoe.gif|left|200px]]<br /><applet load="1hoe" size=" | + | [[Image:1hoe.gif|left|200px]]<br /><applet load="1hoe" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hoe, resolution 2.0Å" /> | caption="1hoe, resolution 2.0Å" /> | ||
'''CRYSTAL STRUCTURE DETERMINATION, REFINEMENT AND THE MOLECULAR MODEL OF THE ALPHA-AMYLASE INHIBITOR HOE-467A'''<br /> | '''CRYSTAL STRUCTURE DETERMINATION, REFINEMENT AND THE MOLECULAR MODEL OF THE ALPHA-AMYLASE INHIBITOR HOE-467A'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal and molecular structure of the alpha-amylase inhibitor | + | The crystal and molecular structure of the alpha-amylase inhibitor Hoe-467A has been determined and refined at high resolution. The polypeptide chain is folded in two triple-stranded sheets, which form a barrel. The topology of folding is as found in the immunoglobulin domains. The amino acid triplet Trp18-Arg19-Tyr20 has an exceptional conformation and position in the molecule and is possibly involved in inhibitory activity. |
==About this Structure== | ==About this Structure== | ||
| - | 1HOE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full crystallographic information is available from [http:// | + | 1HOE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_tendae Streptomyces tendae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Streptomyces tendae]] | [[Category: Streptomyces tendae]] | ||
[[Category: Huber, R.]] | [[Category: Huber, R.]] | ||
| - | [[Category: Pflugrath, J | + | [[Category: Pflugrath, J W.]] |
[[Category: Wiegand, G.]] | [[Category: Wiegand, G.]] | ||
[[Category: glycosidase inhibitor]] | [[Category: glycosidase inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:03:32 2008'' |
Revision as of 11:03, 21 February 2008
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CRYSTAL STRUCTURE DETERMINATION, REFINEMENT AND THE MOLECULAR MODEL OF THE ALPHA-AMYLASE INHIBITOR HOE-467A
Overview
The crystal and molecular structure of the alpha-amylase inhibitor Hoe-467A has been determined and refined at high resolution. The polypeptide chain is folded in two triple-stranded sheets, which form a barrel. The topology of folding is as found in the immunoglobulin domains. The amino acid triplet Trp18-Arg19-Tyr20 has an exceptional conformation and position in the molecule and is possibly involved in inhibitory activity.
About this Structure
1HOE is a Single protein structure of sequence from Streptomyces tendae. Full crystallographic information is available from OCA.
Reference
Crystal structure determination, refinement and the molecular model of the alpha-amylase inhibitor Hoe-467A., Pflugrath JW, Wiegand G, Huber R, Vertesy L, J Mol Biol. 1986 May 20;189(2):383-6. PMID:3489104
Page seeded by OCA on Thu Feb 21 13:03:32 2008
