3lc5
From Proteopedia
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{{STRUCTURE_3lc5| PDB=3lc5 | SCENE= }} | {{STRUCTURE_3lc5| PDB=3lc5 | SCENE= }} | ||
===Selective Benzothiophine Inhibitors of Factor IXa=== | ===Selective Benzothiophine Inhibitors of Factor IXa=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Hemophilia B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300746 300746]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3lc5]] is a 2 chain structure of [[Factor IX]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LC5 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Factor IX|Factor IX]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020121197</ref><references group="xtra"/> |
[[Category: Coagulation factor IXa]] | [[Category: Coagulation factor IXa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Wang, S.]] | [[Category: Wang, S.]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
| - | [[Category: Calcium]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Hydroxylation]] | [[Category: Hydroxylation]] | ||
[[Category: Peptidase s1]] | [[Category: Peptidase s1]] | ||
| - | [[Category: Pharmaceutical]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Protein-inhibitor complex]] | [[Category: Protein-inhibitor complex]] | ||
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[[Category: Sulfation]] | [[Category: Sulfation]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
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Revision as of 16:05, 27 July 2012
Contents |
Selective Benzothiophine Inhibitors of Factor IXa
Template:ABSTRACT PUBMED 20121197
About this Structure
3lc5 is a 2 chain structure of Factor IX with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wang S, Beck R, Burd A, Blench T, Marlin F, Ayele T, Buxton S, Dagostin C, Malic M, Joshi R, Barry J, Sajad M, Cheung C, Shaikh S, Chahwala S, Chander C, Baumgartner C, Holthoff HP, Murray E, Blackney M, Giddings A. Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. PMID:20121197 doi:10.1021/jm901476x
Categories: Coagulation factor IXa | Homo sapiens | Beck, R. | Wang, S. | Blood coagulation | Cleavage on pair of basic residue | Disease mutation | Disulfide bond | Egf-like domain | Gamma-carboxyglutamic acid | Glycoprotein | Hemophilia | Hydrolase | Hydrolase-hydrolase inhibitor complex | Hydroxylation | Peptidase s1 | Phosphoprotein | Protease | Protein-inhibitor complex | Secreted | Serine protease | Sulfation | Zymogen
