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3b2u
From Proteopedia
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{{STRUCTURE_3b2u| PDB=3b2u | SCENE= }} | {{STRUCTURE_3b2u| PDB=3b2u | SCENE= }} | ||
===Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8=== | ===Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8=== | ||
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{{ABSTRACT_PUBMED_18275813}} | {{ABSTRACT_PUBMED_18275813}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3b2u]] is a 24 chain structure of [[Antibody]] and [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B2U OCA]. | |
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| + | ==See Also== | ||
| + | *[[Antibody|Antibody]] | ||
| + | *[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018275813</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Kussie, P.]] | [[Category: Kussie, P.]] | ||
[[Category: Li, S.]] | [[Category: Li, S.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Anti-oncogene]] | [[Category: Anti-oncogene]] | ||
[[Category: Antigen:antibody complex]] | [[Category: Antigen:antibody complex]] | ||
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[[Category: Fab fragment]] | [[Category: Fab fragment]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
| - | [[Category: Immune system | + | [[Category: Immune system-transferase complex]] |
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
| - | [[Category: Ubl conjugation]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:00:22 2009'' | ||
Revision as of 16:19, 27 July 2012
Contents |
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Template:ABSTRACT PUBMED 18275813
About this Structure
3b2u is a 24 chain structure of Antibody and Epidermal Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Li S, Kussie P, Ferguson KM. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure. 2008 Feb;16(2):216-27. PMID:18275813 doi:10.1016/j.str.2007.11.009
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Ferguson, K M. | Kussie, P. | Li, S. | Anti-oncogene | Antigen:antibody complex | Antitumor | Atp-binding | Cell cycle | Cell surface receptor | Disease mutation | Drug | Fab fragment | Glycoprotein | Immune system-transferase complex | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Secreted | Transferase | Transmembrane | Tyrosine-protein kinase
