1hrn
From Proteopedia
(New page: 200px<br /> <applet load="1hrn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hrn, resolution 1.8Å" /> '''HIGH RESOLUTION CRYS...) |
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| - | [[Image:1hrn.gif|left|200px]]<br /> | + | [[Image:1hrn.gif|left|200px]]<br /><applet load="1hrn" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hrn" size=" | + | |
caption="1hrn, resolution 1.8Å" /> | caption="1hrn, resolution 1.8Å" /> | ||
'''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''<br /> | '''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structures of recombinant glycosylated human renin in complex | + | The crystal structures of recombinant glycosylated human renin in complex with several polyhydroxymonoamide inhibitors have been determined at up to 1.8 A resolution. The high resolution structures permit a detailed analysis of the conformation of renin, the interactions between the inhibitors and renin, and the network of ordered water molecules. The polyhydroxymonoamide inhibitors are bound with their backbones in an extended conformation, and with their side-chains occupying the S3 to S1 pockets. The inhibited renin molecules are shown to exist in both the closed and the open conformations. Inhibitors bound to the two distinct forms of renin can assume different conformations at the P3 position. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HRN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, PPP, CPP and IP3 as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1HRN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http:// | + | 1HRN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=PPP:'>PPP</scene>, <scene name='pdbligand=CPP:'>CPP</scene> and <scene name='pdbligand=IP3:'>IP3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1HRN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pepsin]] | [[Category: Pepsin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Anderson, P | + | [[Category: Anderson, P C.]] |
[[Category: Tong, L.]] | [[Category: Tong, L.]] | ||
[[Category: CPP]] | [[Category: CPP]] | ||
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[[Category: aspartic proteinase]] | [[Category: aspartic proteinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:10 2008'' |
Revision as of 11:04, 21 February 2008
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HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS
Contents |
Overview
The crystal structures of recombinant glycosylated human renin in complex with several polyhydroxymonoamide inhibitors have been determined at up to 1.8 A resolution. The high resolution structures permit a detailed analysis of the conformation of renin, the interactions between the inhibitors and renin, and the network of ordered water molecules. The polyhydroxymonoamide inhibitors are bound with their backbones in an extended conformation, and with their side-chains occupying the S3 to S1 pockets. The inhibited renin molecules are shown to exist in both the closed and the open conformations. Inhibitors bound to the two distinct forms of renin can assume different conformations at the P3 position.
Disease
Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]
About this Structure
1HRN is a Single protein structure of sequence from Homo sapiens with , , and as ligands. The following page contains interesting information on the relation of 1HRN with [Pepsin]. Full crystallographic information is available from OCA.
Reference
High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:7608971
Page seeded by OCA on Thu Feb 21 13:04:10 2008
Categories: Homo sapiens | Pepsin | Single protein | Anderson, P C. | Tong, L. | CPP | IP3 | NAG | PPP | Aspartic proteinase
