1hrp
From Proteopedia
(New page: 200px<br /> <applet load="1hrp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hrp, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1hrp.gif|left|200px]]<br /> | + | [[Image:1hrp.gif|left|200px]]<br /><applet load="1hrp" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hrp" size=" | + | |
caption="1hrp, resolution 3.0Å" /> | caption="1hrp, resolution 3.0Å" /> | ||
'''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of human chorionic gonadotropin shows that | + | The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones. |
==About this Structure== | ==About this Structure== | ||
| - | 1HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1HRP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRP OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8202136 8202136] | Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8202136 8202136] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Harris, D | + | [[Category: Harris, D C.]] |
| - | [[Category: Isaacs, N | + | [[Category: Isaacs, N W.]] |
| - | [[Category: Lapthorn, A | + | [[Category: Lapthorn, A J.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: hormone]] | [[Category: hormone]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:18 2008'' |
Revision as of 11:04, 21 February 2008
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CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN
Overview
The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.
About this Structure
1HRP is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136
Page seeded by OCA on Thu Feb 21 13:04:18 2008
