1htm
From Proteopedia
(New page: 200px<br /> <applet load="1htm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1htm, resolution 2.5Å" /> '''STRUCTURE OF INFLUEN...) |
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'''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION'''<br /> | '''STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Low pH induces a conformational change in the influenza virus | + | Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered. |
==About this Structure== | ==About this Structure== | ||
| - | 1HTM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The following page contains interesting information on the relation of 1HTM with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http:// | + | 1HTM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The following page contains interesting information on the relation of 1HTM with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Uncultured beta proteobacterium umtra-608]] | [[Category: Uncultured beta proteobacterium umtra-608]] | ||
| - | [[Category: Bullough, P | + | [[Category: Bullough, P A.]] |
| - | [[Category: Hughson, F | + | [[Category: Hughson, F M.]] |
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: influenza virus hemagglutinin]] | [[Category: influenza virus hemagglutinin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:41 2008'' |
Revision as of 11:04, 21 February 2008
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STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION
Overview
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.
About this Structure
1HTM is a Protein complex structure of sequences from Uncultured beta proteobacterium umtra-608. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525
Page seeded by OCA on Thu Feb 21 13:04:41 2008
