1hxy
From Proteopedia
(New page: 200px<br /> <applet load="1hxy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hxy, resolution 2.6Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1hxy.gif|left|200px]]<br /> | + | [[Image:1hxy.gif|left|200px]]<br /><applet load="1hxy" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hxy" size=" | + | |
caption="1hxy, resolution 2.6Å" /> | caption="1hxy, resolution 2.6Å" /> | ||
'''CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II'''<br /> | '''CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major | + | The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). The superantigen binds on top of HLA-DR1 in a completely different way from earlier co-crystallized superantigens from S.aureus. SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA-DR1. The structure suggests that all superantigens interacting with MHC class II in a zinc-dependent manner present the superantigen in a common way. This suggests a new model for ternary complex formation with the T-cell receptor (TCR), in which a contact between the TCR and the MHC class II is unlikely. |
==About this Structure== | ==About this Structure== | ||
| - | 1HXY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1HXY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Nilsson, H.]] | [[Category: Nilsson, H.]] | ||
[[Category: Petersson, K.]] | [[Category: Petersson, K.]] | ||
| - | [[Category: Svensson, L | + | [[Category: Svensson, L A.]] |
[[Category: Walse, B.]] | [[Category: Walse, B.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: complex]] | [[Category: complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:05:56 2008'' |
Revision as of 11:05, 21 February 2008
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN H IN COMPLEX WITH HUMAN MHC CLASS II
Overview
The three-dimensional structure of a bacterial superantigen, Staphylococcus aureus enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA-DR1) has been determined by X-ray crystallography to 2.6 A resolution (1HXY). The superantigen binds on top of HLA-DR1 in a completely different way from earlier co-crystallized superantigens from S.aureus. SEH interacts with high affinity through a zinc ion with the beta1 chain of HLA-DR1 and also with the peptide presented by HLA-DR1. The structure suggests that all superantigens interacting with MHC class II in a zinc-dependent manner present the superantigen in a common way. This suggests a new model for ternary complex formation with the T-cell receptor (TCR), in which a contact between the TCR and the MHC class II is unlikely.
About this Structure
1HXY is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence., Petersson K, Hakansson M, Nilsson H, Forsberg G, Svensson LA, Liljas A, Walse B, EMBO J. 2001 Jul 2;20(13):3306-12. PMID:11432818
Page seeded by OCA on Thu Feb 21 13:05:56 2008
