1i51
From Proteopedia
(New page: 200px<br /> <applet load="1i51" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i51, resolution 2.45Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1i51.gif|left|200px]]<br /> | + | [[Image:1i51.gif|left|200px]]<br /><applet load="1i51" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1i51, resolution 2.45Å" /> | caption="1i51, resolution 2.45Å" /> | ||
'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''<br /> | '''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The inhibitor of apoptosis (IAP) proteins suppress cell death by | + | The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. Strikingly, despite a reversal of relative orientation, a subset of interactions between caspase-7 and XIAP closely resemble those between caspase-7 and its tetrapeptide inhibitor DEVD-CHO. Our biochemical and structural analyses reveal that the BIR domains are dispensable for the inhibition of caspase-3 and -7. This study provides a structural basis for the design of the next-generation caspase inhibitors. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1I51 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1I51 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I51 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:08:06 2008'' |
Revision as of 11:08, 21 February 2008
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CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP
Contents |
Overview
The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. Strikingly, despite a reversal of relative orientation, a subset of interactions between caspase-7 and XIAP closely resemble those between caspase-7 and its tetrapeptide inhibitor DEVD-CHO. Our biochemical and structural analyses reveal that the BIR domains are dispensable for the inhibition of caspase-3 and -7. This study provides a structural basis for the design of the next-generation caspase inhibitors.
Disease
Known diseases associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]
About this Structure
1I51 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis of caspase-7 inhibition by XIAP., Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Cell. 2001 Mar 9;104(5):769-80. PMID:11257230
Page seeded by OCA on Thu Feb 21 13:08:06 2008
Categories: Homo sapiens | Protein complex | Chai, J. | Shi, Y. | Apoptosis | Caspase | Iap | Protease
