4g31
From Proteopedia
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| - | + | [[Image:4g31.jpg|left|200px]] | |
| - | + | {{STRUCTURE_4g31| PDB=4g31 | SCENE= }} | |
| - | + | ===Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution=== | |
| - | + | {{ABSTRACT_PUBMED_22827572}} | |
| + | |||
| + | ==About this Structure== | ||
| + | [[4g31]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G31 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:022827572</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Axten, J M.]] | ||
| + | [[Category: Gampe, R T.]] | ||
| + | [[Category: Catalytic domain]] | ||
| + | [[Category: Deletion mutant]] | ||
| + | [[Category: Synthetic inhibitor]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 05:21, 8 August 2012
Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution
Template:ABSTRACT PUBMED 22827572
About this Structure
4g31 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Axten JM, Medina JR, Feng Y, Shu A, Romeril S, Grant S, Li WH, Heerding DA, Minthorn E, Mencken T, Atkins C, Liu Q, Rabindran S, Kumat R, Hong X, Goetz A, Stanley TB, Taylor D, Sigethy S, Tomberlin GH, Hassell A, Shewchuk LM, Gampe R. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-p yrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of PKR-like Endoplasmic Reticulum Kinase (PERK). J Med Chem. 2012 Jul 24. PMID:22827572 doi:10.1021/jm300713s
