1iao
From Proteopedia
(New page: 200px<br /><applet load="1iao" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iao, resolution 2.6Å" /> '''CLASS II MHC I-AD IN ...) |
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| - | [[Image:1iao.gif|left|200px]]<br /><applet load="1iao" size=" | + | [[Image:1iao.gif|left|200px]]<br /><applet load="1iao" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1iao, resolution 2.6Å" /> | caption="1iao, resolution 2.6Å" /> | ||
'''CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339'''<br /> | '''CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the structures of I-Ad covalently linked to an | + | We have determined the structures of I-Ad covalently linked to an ovalbumin peptide (OVA323-339) and to an influenza virus hemagglutinin peptide (HA126-138). The floor of the peptide-binding groove contains an unusual beta bulge, not seen in I-E and DR structures, that affects numerous interactions between the alpha and beta chains and bound peptide. Unlike other MHC-peptide complexes, the peptides do not insert any large anchor residues into the binding pockets of the shallow I-Ad binding groove. The previously identified six-residue "core" binding motif of I-Ad occupies only the P4 to P9 pockets, implying that specificity of T cell receptor recognition of I-Ad-peptide complexes can be accomplished by peptides that only partially fill the MHC groove. |
==About this Structure== | ==About this Structure== | ||
| - | 1IAO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1IAO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Peterson, P | + | [[Category: Peterson, P A.]] |
| - | [[Category: Scott, C | + | [[Category: Scott, C A.]] |
[[Category: Teyton, L.]] | [[Category: Teyton, L.]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: class ii mhc]] | [[Category: class ii mhc]] | ||
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[[Category: ovalbumin peptide]] | [[Category: ovalbumin peptide]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:51 2008'' |
Revision as of 11:09, 21 February 2008
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CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339
Overview
We have determined the structures of I-Ad covalently linked to an ovalbumin peptide (OVA323-339) and to an influenza virus hemagglutinin peptide (HA126-138). The floor of the peptide-binding groove contains an unusual beta bulge, not seen in I-E and DR structures, that affects numerous interactions between the alpha and beta chains and bound peptide. Unlike other MHC-peptide complexes, the peptides do not insert any large anchor residues into the binding pockets of the shallow I-Ad binding groove. The previously identified six-residue "core" binding motif of I-Ad occupies only the P4 to P9 pockets, implying that specificity of T cell receptor recognition of I-Ad-peptide complexes can be accomplished by peptides that only partially fill the MHC groove.
About this Structure
1IAO is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues., Scott CA, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 Mar;8(3):319-29. PMID:9529149
Page seeded by OCA on Thu Feb 21 13:09:51 2008
Categories: Mus musculus | Protein complex | Peterson, P A. | Scott, C A. | Teyton, L. | Wilson, I A. | NAG | Class ii mhc | I-a | Mhc ii | Ovalbumin peptide
