1nox
From Proteopedia
(New page: 200px<br /> <applet load="1nox" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nox, resolution 1.59Å" /> '''NADH OXIDASE FROM T...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1NOX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with FMN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.99.3 1.6.99.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NOX OCA]]. | + | 1NOX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with FMN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/NADH_dehydrogenase NADH dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.99.3 1.6.99.3]]. Structure known Active Site: COF. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NOX OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8846223 8846223] | Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8846223 8846223] | ||
| + | [[Category: NADH dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
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[[Category: thermophile]] | [[Category: thermophile]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:19:05 2007'' |
Revision as of 12:14, 30 October 2007
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NADH OXIDASE FROM THERMUS THERMOPHILUS
Overview
The crystal structures of the flavin adenine dinucleotide (FAD) and flavin, mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus, thermophilus have been determined by isomorphous and molecular replacement, and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6%, respectively. The structure of the homodimeric enzyme consists of a, central 4-stranded antiparallel beta-sheet covered by helices, a more, flexible domain formed by two helices, and a C-terminal excursion, connecting the subunits. The active sites are located in a deep cleft, between the subunits. The binding site of the flavin cofactor lacks the, common nucleotide binding fold and is different from the FMN binding site, found in flavodoxins.
About this Structure
1NOX is a [Single protein] structure of sequence from [Thermus thermophilus] with FMN as [ligand]. Active as [NADH dehydrogenase], with EC number [1.6.99.3]. Structure known Active Site: COF. Full crystallographic information is available from [OCA].
Reference
Crystal structure of NADH oxidase from Thermus thermophilus., Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD, Nat Struct Biol. 1995 Dec;2(12):1109-14. PMID:8846223
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