1ibr
From Proteopedia
(New page: 200px<br /> <applet load="1ibr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ibr, resolution 2.30Å" /> '''COMPLEX OF RAN WITH...) |
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| - | [[Image:1ibr.gif|left|200px]]<br /> | + | [[Image:1ibr.gif|left|200px]]<br /><applet load="1ibr" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ibr" size=" | + | |
caption="1ibr, resolution 2.30Å" /> | caption="1ibr, resolution 2.30Å" /> | ||
'''COMPLEX OF RAN WITH IMPORTIN BETA'''<br /> | '''COMPLEX OF RAN WITH IMPORTIN BETA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Transport receptors of the Importin beta family shuttle between the | + | Transport receptors of the Importin beta family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes. They interact specifically with the GTP-binding protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from Importin beta. The structure of Importin beta shows 10 tandem repeats resembling HEAT and Armadillo motifs. They form an irregular crescent, the concave site of which forms the interface with Ran-triphosphate. The importin-binding site of Ran does not overlap with that of the Ran-binding domain of RanBP2. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IBR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GNP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1IBR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GNP:'>GNP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Goerlich, D.]] | [[Category: Goerlich, D.]] | ||
[[Category: Kutay, U.]] | [[Category: Kutay, U.]] | ||
| - | [[Category: Vetter, I | + | [[Category: Vetter, I R.]] |
[[Category: Wittinghofer, A.]] | [[Category: Wittinghofer, A.]] | ||
[[Category: GNP]] | [[Category: GNP]] | ||
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[[Category: small gtpase; nuclear transport receptor]] | [[Category: small gtpase; nuclear transport receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:09 2008'' |
Revision as of 11:10, 21 February 2008
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COMPLEX OF RAN WITH IMPORTIN BETA
Contents |
Overview
Transport receptors of the Importin beta family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes. They interact specifically with the GTP-binding protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from Importin beta. The structure of Importin beta shows 10 tandem repeats resembling HEAT and Armadillo motifs. They form an irregular crescent, the concave site of which forms the interface with Ran-triphosphate. The importin-binding site of Ran does not overlap with that of the Ran-binding domain of RanBP2.
Disease
Known diseases associated with this structure: Osteolysis, familial expansile OMIM:[603499], Paget disease of bone OMIM:[603499]
About this Structure
1IBR is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:10367892
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