1ico
From Proteopedia
(New page: 200px<br /><applet load="1ico" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ico" /> '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MI...) |
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| - | [[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size=" | + | [[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ico" /> | caption="1ico" /> | ||
'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''<br /> | '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Here we report the creation of a predominantly beta-structured | + | Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water. |
==About this Structure== | ==About this Structure== | ||
| - | 1ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Imperiali, B.]] | [[Category: Imperiali, B.]] | ||
| - | [[Category: Ottesen, J | + | [[Category: Ottesen, J J.]] |
[[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | [[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:30 2008'' |
Revision as of 11:10, 21 February 2008
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SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX
Overview
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
About this Structure
1ICO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623
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