1w70
From Proteopedia
(New page: 200px<br /> <applet load="1w70" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w70, resolution 1.46Å" /> '''SH3 DOMAIN OF P40PH...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W70 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ACE and TFA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W70 OCA]]. | + | 1W70 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ACE and TFA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W70 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: sh3 domain]] | [[Category: sh3 domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:19:36 2007'' |
Revision as of 12:14, 30 October 2007
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SH3 DOMAIN OF P40PHOX COMPLEXED WITH C-TERMINAL POLYPROLINE REGION OF P47PHOX
Overview
The neutrophil NADPH oxidase produces superoxide anions in response to, infection. This reaction is activated by association of cytosolic factors, p47phox and p67phox, and a small G protein Rac with the membranous, flavocytochrome b558. Another cytosolic factor, p40phox, is associated to, the complex and is reported to play regulatory roles. Initiation of the, NADPH oxidase activation cascade has been reported as consecutive to, phosphorylation on serines 359/370 and 379 of the p47phox C terminus., These serines surround a polyproline motif that can interact with the Src, homology 3 (SH3) module of p40phox (SH3p40) or the C-terminal SH3 of, p67phox (C-SH3p67). The latter one presents a higher affinity in the, resting state for p47phox. A change in SH3 binding preference following, ... [(full description)]
About this Structure
1W70 is a [Protein complex] structure of sequences from [Homo sapiens] with SO4, ACE and TFA as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains., Massenet C, Chenavas S, Cohen-Addad C, Dagher MC, Brandolin G, Pebay-Peyroula E, Fieschi F, J Biol Chem. 2005 Apr 8;280(14):13752-61. Epub 2005 Jan 18. PMID:15657040
Page seeded by OCA on Tue Oct 30 14:19:36 2007
Categories: Homo sapiens | Protein complex | Brandolin, G. | Chenavas, S. | Cohen-Addad, C. | Dagher, M.C. | Fieschi, F. | Massenet, C. | Pebay-Peyroula, E. | ACE | SO4 | TFA | Nadph oxidase | P40phox | P47phox | Polyproline | Sh3 domain
