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1w7j

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(New page: 200px<br /> <applet load="1w7j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w7j, resolution 2.&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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==About this Structure==
==About this Structure==
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1W7J is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, ADP and BEF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7J OCA]].
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1W7J is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]] and [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, ADP and BEF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7J OCA]].
==Reference==
==Reference==
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[[Category: unconventional myosin]]
[[Category: unconventional myosin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:51:53 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:19:52 2007''

Revision as of 12:15, 30 October 2007

Image:1w7j.gif

1w7j, resolution 2.Å

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CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX- NEAR RIGOR

Overview

The molecular motor, myosin, undergoes conformational changes in order to, convert chemical energy into force production. Based on kinetic and, structural considerations, we assert that three crystal forms of the, myosin V motor delineate the conformational changes that myosin motors, undergo upon detachment from actin. First, a motor domain structure, demonstrates that nucleotide-free myosin V adopts a specific state, (rigor-like) that is not influenced by crystal packing. A second structure, reveals an actomyosin state that favors rapid release of ADP, and differs, from the rigor-like state by a P-loop rearrangement. Comparison of these, structures with a third structure, a 2.0 angstroms resolution structure of, the motor bound to an ATP analog, illuminates the structural features that, ... [(full description)]

About this Structure

1W7J is a [Protein complex] structure of sequences from [Gallus gallus] and [Homo sapiens] with MG, ADP and BEF as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:15510214

Page seeded by OCA on Tue Oct 30 14:19:52 2007

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