This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ih1
From Proteopedia
(New page: 200px<br /><applet load="1ih1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ih1, resolution 2.0Å" /> '''Crystal Structure of ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1ih1.gif|left|200px]]<br /><applet load="1ih1" size=" | + | [[Image:1ih1.gif|left|200px]]<br /><applet load="1ih1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ih1, resolution 2.0Å" /> | caption="1ih1, resolution 2.0Å" /> | ||
'''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''<br /> | '''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The transition between B- and A-DNA was first observed nearly 50 years | + | The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway. |
==About this Structure== | ==About this Structure== | ||
| - | 1IH1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and NCO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1IH1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=NCO:'>NCO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH1 OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Henderson, K.]] | [[Category: Henderson, K.]] | ||
| - | [[Category: Ho, P | + | [[Category: Ho, P S.]] |
| - | [[Category: Vargason, J | + | [[Category: Vargason, J M.]] |
[[Category: MG]] | [[Category: MG]] | ||
[[Category: NCO]] | [[Category: NCO]] | ||
| Line 21: | Line 21: | ||
[[Category: structural transition]] | [[Category: structural transition]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:45 2008'' |
Revision as of 11:11, 21 February 2008
|
Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms
Overview
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
About this Structure
1IH1 is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969
Page seeded by OCA on Thu Feb 21 13:11:45 2008
