1w7x
From Proteopedia
(New page: 200px<br /> <applet load="1w7x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w7x, resolution 1.80Å" /> '''FACTOR7- 413 COMPLE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W7X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, SO4, 413 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA]]. | + | 1W7X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA, SO4, 413 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA]]. |
==Reference== | ==Reference== | ||
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16213138 16213138] | Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16213138 16213138] | ||
| + | [[Category: Coagulation factor VIIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:20:00 2007'' |
Revision as of 12:15, 30 October 2007
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FACTOR7- 413 COMPLEX
Overview
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway.
About this Structure
1W7X is a [Protein complex] structure of sequences from [Homo sapiens] with CA, SO4, 413 and GOL as [ligands]. Active as [Coagulation factor VIIa], with EC number [3.4.21.21]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138
Page seeded by OCA on Tue Oct 30 14:20:00 2007
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Ackermann, J. | Alig, L. | Banner, D.W. | Boehm, H.J. | Groebke-Zbinden, K. | Hilpert, K. | Kuehne, H. | Lave, T. | Obst-Sander, U. | Riederer, M. | Stahl, M. | Tschopp, T.B. | Weber, L. | Wessel, H.P. | 413 | CA | GOL | SO4 | Coagulation | Enzyme complex | Serine protease
