1ih6
From Proteopedia
(New page: 200px<br /><applet load="1ih6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ih6, resolution 1.45Å" /> '''Multi-Conformation C...) |
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| - | [[Image:1ih6.gif|left|200px]]<br /><applet load="1ih6" size=" | + | [[Image:1ih6.gif|left|200px]]<br /><applet load="1ih6" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ih6, resolution 1.45Å" /> | caption="1ih6, resolution 1.45Å" /> | ||
'''Multi-Conformation Crystal Structure of GGBr5CGCC'''<br /> | '''Multi-Conformation Crystal Structure of GGBr5CGCC'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The transition between B- and A-DNA was first observed nearly 50 years | + | The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway. |
==About this Structure== | ==About this Structure== | ||
| - | 1IH6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1IH6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Henderson, K.]] | [[Category: Henderson, K.]] | ||
| - | [[Category: Ho, P | + | [[Category: Ho, P S.]] |
| - | [[Category: Vargason, J | + | [[Category: Vargason, J M.]] |
[[Category: b to a dna transition]] | [[Category: b to a dna transition]] | ||
[[Category: dna transition]] | [[Category: dna transition]] | ||
[[Category: structural transition]] | [[Category: structural transition]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:47 2008'' |
Revision as of 11:11, 21 February 2008
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Multi-Conformation Crystal Structure of GGBr5CGCC
Overview
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
About this Structure
1IH6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969
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