3fyg
From Proteopedia
(New page: 200px<br /> <applet load="3fyg" size="450" color="white" frame="true" align="right" spinBox="true" caption="3fyg, resolution 2.20Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 3FYG is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with GPR as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3FYG OCA]]. | + | 3FYG is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with GPR as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Structure known Active Sites: AVA and AVB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3FYG OCA]]. |
==Reference== | ==Reference== | ||
Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine., Xiao G, Parsons JF, Tesh K, Armstrong RN, Gilliland GL, J Mol Biol. 1998 Aug 14;281(2):323-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9698551 9698551] | Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine., Xiao G, Parsons JF, Tesh K, Armstrong RN, Gilliland GL, J Mol Biol. 1998 Aug 14;281(2):323-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9698551 9698551] | ||
| + | [[Category: Glutathione transferase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: unnatural amino acid]] | [[Category: unnatural amino acid]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:20:14 2007'' |
Revision as of 12:15, 30 October 2007
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CRYSTAL STRUCTURE OF TETRADECA-(3-FLUOROTYROSYL)-GLUTATHIONE S-TRANSFERASE
Overview
The structure of the tetradeca-(3-fluorotyrosyl) M1-1 GSH transferase, (3-FTyr GSH transferase), a protein in which tyrosine residues are, globally substituted by 3-fluorotyrosines has been determined at 2.2 A, resolution. This variant was produced to study the effect on the enzymatic, mechanism and the structure was undertaken to assess how the presence of, the 3-fluorotyrosyl residue influences the protein conformation and hence, its function. Although fluorinated amino acid residues have frequently, been used in biochemical and NMR investigations of proteins, no structure, of a protein that has been globally substituted with a fluorinated amino, acid has previously been reported. Thus, this structure represents the, first crystal structure of such a protein containing a library of 14 ... [(full description)]
About this Structure
3FYG is a [Single protein] structure of sequence from [Rattus norvegicus] with GPR as [ligand]. Active as [Glutathione transferase], with EC number [2.5.1.18]. Structure known Active Sites: AVA and AVB. Full crystallographic information is available from [OCA].
Reference
Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine., Xiao G, Parsons JF, Tesh K, Armstrong RN, Gilliland GL, J Mol Biol. 1998 Aug 14;281(2):323-39. PMID:9698551
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