1iiu
From Proteopedia
(New page: 200px<br /><applet load="1iiu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iiu, resolution 2.50Å" /> '''Chicken plasma retin...) |
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| - | [[Image:1iiu.jpg|left|200px]]<br /><applet load="1iiu" size=" | + | [[Image:1iiu.jpg|left|200px]]<br /><applet load="1iiu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1iiu, resolution 2.50Å" /> | caption="1iiu, resolution 2.50Å" /> | ||
'''Chicken plasma retinol-binding protein (RBP)'''<br /> | '''Chicken plasma retinol-binding protein (RBP)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the specific carrier of retinol (retinol-binding | + | The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs. |
==About this Structure== | ==About this Structure== | ||
| - | 1IIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CD and RTL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1IIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=RTL:'>RTL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: retinol]] | [[Category: retinol]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:22 2008'' |
Revision as of 11:12, 21 February 2008
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Chicken plasma retinol-binding protein (RBP)
Overview
The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.
About this Structure
1IIU is a Single protein structure of sequence from Gallus gallus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of chicken plasma retinol-binding protein., Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R, Biochim Biophys Acta. 2001 Nov 26;1550(1):64-9. PMID:11738088
Page seeded by OCA on Thu Feb 21 13:12:22 2008
Categories: Gallus gallus | Single protein | Berni, R. | Calderone, V. | Zanotti, G. | CD | RTL | Rbp | Retinol
