1m5i

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[[Image:1m5i.png|left|200px]]
[[Image:1m5i.png|left|200px]]
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{{STRUCTURE_1m5i| PDB=1m5i | SCENE= }}
{{STRUCTURE_1m5i| PDB=1m5i | SCENE= }}
===Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC===
===Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC===
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{{ABSTRACT_PUBMED_12070164}}
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==Disease==
 
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Known disease associated with this structure: Adenoma, periampullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Adenomatous polyposis coli OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Brain tumor-polyposis syndrome 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Desmoid disease, hereditary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Gardner syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Gastric cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Hepatoblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]]
 
==About this Structure==
==About this Structure==
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1M5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5I OCA].
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[[1m5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5I OCA].
==Reference==
==Reference==
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The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)., Tickenbrock L, Cramer J, Vetter IR, Muller O, J Biol Chem. 2002 Aug 30;277(35):32332-8. Epub 2002 Jun 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12070164 12070164]
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<ref group="xtra">PMID:012070164</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
 
[[Category: Cramer, J.]]
[[Category: Cramer, J.]]
[[Category: Mueller, O.]]
[[Category: Mueller, O.]]
[[Category: Tickenbrock, L.]]
[[Category: Tickenbrock, L.]]
[[Category: Vetter, I R.]]
[[Category: Vetter, I R.]]
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[[Category: Antitumor protein]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:15:29 2008''
 

Revision as of 17:47, 14 August 2012

Template:STRUCTURE 1m5i

Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC

Template:ABSTRACT PUBMED 12070164

About this Structure

1m5i is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Tickenbrock L, Cramer J, Vetter IR, Muller O. The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1). J Biol Chem. 2002 Aug 30;277(35):32332-8. Epub 2002 Jun 17. PMID:12070164 doi:10.1074/jbc.M203990200

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