311d

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Revision as of 17:54, 14 August 2012

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Template:STRUCTURE 311d

THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2

Template:ABSTRACT PUBMED 9162901

About this Structure

311d is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Clark GR, Boykin DW, Czarny A, Neidle S. Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition. Nucleic Acids Res. 1997 Apr 15;25(8):1510-5. PMID:9162901
• Nguyen B, Neidle S, Wilson WD. A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res. 2009 Jan 20;42(1):11-21. PMID:18798655 doi:10.1021/ar800016q