1izy
From Proteopedia
(New page: 200px<br /><applet load="1izy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1izy, resolution 2.80Å" /> '''Crystal structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1izy.jpg|left|200px]]<br /><applet load="1izy" size=" | + | [[Image:1izy.jpg|left|200px]]<br /><applet load="1izy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1izy, resolution 2.80Å" /> | caption="1izy, resolution 2.80Å" /> | ||
'''Crystal structure of Hsp31'''<br /> | '''Crystal structure of Hsp31'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose | + | Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed. |
==About this Structure== | ==About this Structure== | ||
| - | 1IZY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | + | 1IZY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZY OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cha, S | + | [[Category: Cha, S S.]] |
| - | [[Category: Lee, S | + | [[Category: Lee, S J.]] |
[[Category: alpha-beta sandwitch]] | [[Category: alpha-beta sandwitch]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:17:25 2008'' |
Revision as of 11:17, 21 February 2008
|
Crystal structure of Hsp31
Overview
Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.
About this Structure
1IZY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain., Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS, J Biol Chem. 2003 Nov 7;278(45):44552-9. Epub 2003 Aug 25. PMID:12939276
Page seeded by OCA on Thu Feb 21 13:17:25 2008
