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Scorpion toxin
From Proteopedia
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Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels. | Both methods led to the identification of two regions on the surface of LqhαIT that participate in binding of the toxin to neurotoxin receptor site-3 on sodium channels. | ||
</StructureSection> | </StructureSection> | ||
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| + | ==3D structures of scorpion toxin== | ||
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| + | [[1pnh]] – AmST P05-NH2 – ''Androctonus mauretanicus'' – NMR<BR /> | ||
| + | [[1acw]] - AmST P01 – NMR<BR /> | ||
| + | [[2sn3]] – ST – ''Centruroides exilicauda''<BR /> | ||
| + | [[1ptx]] – ST – ''Androctonus australis''<BR /> | ||
| + | [[1sco]] – ST OSK1 – ''Orthochirus scrobiculosus'' – NMR<BR /> | ||
| + | [[1lqh]], [[1lqi]] – ST α – ''Leiurus quinquestriatus hebraeus'' – NMR<BR /> | ||
| + | [[1snb]] – MmST BMK M8 – ''Mesobuthus martensii''<BR /> | ||
| + | [[1sn1]] - MmST BMK M1<BR /> | ||
| + | [[1pvz]] - MmST BMP07 – NMR<BR /> | ||
| + | [[2k9o]] – ST VM24 – synthetic - NMR<BR /> | ||
| + | |||
==References== | ==References== | ||
(1) Tugarinov, V., Kustanovich, I., Zilberberg, N., Gurevitz, M. Anglister, J. Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity. Biochemistry 36, 2414-24 (1997). | (1) Tugarinov, V., Kustanovich, I., Zilberberg, N., Gurevitz, M. Anglister, J. Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity. Biochemistry 36, 2414-24 (1997). | ||
Revision as of 09:31, 16 August 2012
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3D structures of scorpion toxin
1pnh – AmST P05-NH2 – Androctonus mauretanicus – NMR
1acw - AmST P01 – NMR
2sn3 – ST – Centruroides exilicauda
1ptx – ST – Androctonus australis
1sco – ST OSK1 – Orthochirus scrobiculosus – NMR
1lqh, 1lqi – ST α – Leiurus quinquestriatus hebraeus – NMR
1snb – MmST BMK M8 – Mesobuthus martensii
1sn1 - MmST BMK M1
1pvz - MmST BMP07 – NMR
2k9o – ST VM24 – synthetic - NMR
References
(1) Tugarinov, V., Kustanovich, I., Zilberberg, N., Gurevitz, M. Anglister, J. Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity. Biochemistry 36, 2414-24 (1997). PMID: 9054546
(2) Karbat, I., Frolow, F., Froy, O., Gilles, N., Cohen, L., Turkov, M., Gordon, D. Gurevitz, M. Molecular basis of the high insecticidal potency of scorpion alpha-toxins. J. Biol. Chem. 279, 31679-86 (2004). PMID: 15133045
(3) Schnur, E., Turkov, M., Kahn, R., Gordon, D., Gurevitz, M., Anglister, J. NMR Analysis of interaction of Lqh(alpha)IT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3), 911-21 (2008).
PMID: 18154318
Created with the participation of Eran Hodis, Einat Schnur, Jaime Prilusky
