1j4r
From Proteopedia
(New page: 200px<br /> <applet load="1j4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j4r, resolution 1.80Å" /> '''FK506 BINDING PROTE...) |
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| - | [[Image:1j4r.gif|left|200px]]<br /> | + | [[Image:1j4r.gif|left|200px]]<br /><applet load="1j4r" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1j4r" size=" | + | |
caption="1j4r, resolution 1.80Å" /> | caption="1j4r, resolution 1.80Å" /> | ||
'''FK506 BINDING PROTEIN COMPLEXED WITH FKB-001'''<br /> | '''FK506 BINDING PROTEIN COMPLEXED WITH FKB-001'''<br /> | ||
==Overview== | ==Overview== | ||
| - | [structure: see text] 2-Aryl-2,2-difluoroacetamido-proline and pipecolate | + | [structure: see text] 2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that the fluorine atoms participate in discrete interactions with the Phe36 phenyl ring and the Tyr26 hydroxyl group, with the latter resembling a moderate-to-weak hydrogen bond. |
==About this Structure== | ==About this Structure== | ||
| - | 1J4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, 001 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http:// | + | 1J4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=001:'>001</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J4R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rotamase]] | [[Category: rotamase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:18:53 2008'' |
Revision as of 11:18, 21 February 2008
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FK506 BINDING PROTEIN COMPLEXED WITH FKB-001
Overview
[structure: see text] 2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that the fluorine atoms participate in discrete interactions with the Phe36 phenyl ring and the Tyr26 hydroxyl group, with the latter resembling a moderate-to-weak hydrogen bond.
About this Structure
1J4R is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Full crystallographic information is available from OCA.
Reference
2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies., Dubowchik GM, Vrudhula VM, Dasgupta B, Ditta J, Chen T, Sheriff S, Sipman K, Witmer M, Tredup J, Vyas DM, Verdoorn TA, Bollini S, Vinitsky A, Org Lett. 2001 Dec 13;3(25):3987-90. PMID:11735566
Page seeded by OCA on Thu Feb 21 13:18:53 2008
Categories: Homo sapiens | Peptidylprolyl isomerase | Single protein | Sheriff, S. | 001 | GOL | SO4 | Inhibitor | Rotamase
