1j5e
From Proteopedia
(New page: 200px<br /><applet load="1j5e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j5e, resolution 3.05Å" /> '''Structure of the The...) |
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| - | [[Image:1j5e.gif|left|200px]]<br /><applet load="1j5e" size=" | + | [[Image:1j5e.gif|left|200px]]<br /><applet load="1j5e" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1j5e, resolution 3.05Å" /> | caption="1j5e, resolution 3.05Å" /> | ||
'''Structure of the Thermus thermophilus 30S Ribosomal Subunit'''<br /> | '''Structure of the Thermus thermophilus 30S Ribosomal Subunit'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Genetic information encoded in messenger RNA is translated into protein by | + | Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 A resolution. The final atomic model rationalizes over four decades of biochemical data on the ribosome, and provides a wealth of information about RNA and protein structure, protein-RNA interactions and ribosome assembly. It is also a structural basis for analysis of the functions of the 30S subunit, such as decoding, and for understanding the action of antibiotics. The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography. |
==About this Structure== | ==About this Structure== | ||
| - | 1J5E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with ZN and UNX as [http://en.wikipedia.org/wiki/ligands ligands]. This structure | + | 1J5E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1FJF. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5E OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Brodersen, D | + | [[Category: Brodersen, D E.]] |
| - | [[Category: Carter, A | + | [[Category: Carter, A P.]] |
[[Category: Hartsch, T.]] | [[Category: Hartsch, T.]] | ||
| - | [[Category: Jr., W | + | [[Category: Jr., W M.Clemons.]] |
[[Category: Morgan-Warren, R.]] | [[Category: Morgan-Warren, R.]] | ||
[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
[[Category: Vonrhein, C.]] | [[Category: Vonrhein, C.]] | ||
| - | [[Category: Wimberly, B | + | [[Category: Wimberly, B T.]] |
[[Category: UNX]] | [[Category: UNX]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: ribosome]] | [[Category: ribosome]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:19:07 2008'' |
Revision as of 11:19, 21 February 2008
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Structure of the Thermus thermophilus 30S Ribosomal Subunit
Overview
Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 A resolution. The final atomic model rationalizes over four decades of biochemical data on the ribosome, and provides a wealth of information about RNA and protein structure, protein-RNA interactions and ribosome assembly. It is also a structural basis for analysis of the functions of the 30S subunit, such as decoding, and for understanding the action of antibiotics. The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography.
About this Structure
1J5E is a Protein complex structure of sequences from Thermus thermophilus with and as ligands. This structure supersedes the now removed PDB entry 1FJF. Full crystallographic information is available from OCA.
Reference
Structure of the 30S ribosomal subunit., Wimberly BT, Brodersen DE, Clemons WM Jr, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V, Nature. 2000 Sep 21;407(6802):327-39. PMID:11014182
Page seeded by OCA on Thu Feb 21 13:19:07 2008
