1bt3
From Proteopedia
(New page: 200px<br /> <applet load="1bt3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bt3, resolution 2.50Å" /> '''CATECHOL OXIDASE FR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BT3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]] with C2O as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT3 OCA]]. | + | 1BT3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]] with C2O as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1]]. Structure known Active Sites: CUA and CUB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT3 OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of a plant catechol oxidase containing a dicopper center., Klabunde T, Eicken C, Sacchettini JC, Krebs B, Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9846879 9846879] | Crystal structure of a plant catechol oxidase containing a dicopper center., Klabunde T, Eicken C, Sacchettini JC, Krebs B, Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9846879 9846879] | ||
| + | [[Category: Catechol oxidase]] | ||
[[Category: Ipomoea batatas]] | [[Category: Ipomoea batatas]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ipomoea batatas]] | [[Category: ipomoea batatas]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:23:56 2007'' |
Revision as of 12:19, 30 October 2007
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CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES) IN THE NATIVE CU(II)-CU(II) STATE
Overview
Catechol oxidases are ubiquitous plant enzymes containing a dinuclear, copper center. In the wound-response mechanism of the plant they catalyze, the oxidation of a broad range of ortho-diphenols to the corresponding, o-quinones coupled with the reduction of oxygen to water. The crystal, structures of the enzyme from sweet potato in the resting dicupric, Cu(II)-Cu(II) state, the reduced dicuprous Cu(I)-Cu(I) form, and in, complex with the inhibitor phenylthiourea were analyzed. The catalytic, copper center is accommodated in a central four-helix-bundle located in a, hydrophobic pocket close to the surface. Both metal binding sites are, composed of three histidine ligands. His 109, ligated to the CuA site, is, covalently linked to Cys 92 by an unusual thioether bond. Based on, biochemical, ... [(full description)]
About this Structure
1BT3 is a [Single protein] structure of sequence from [Ipomoea batatas] with C2O as [ligand]. Active as [Catechol oxidase], with EC number [1.10.3.1]. Structure known Active Sites: CUA and CUB. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a plant catechol oxidase containing a dicopper center., Klabunde T, Eicken C, Sacchettini JC, Krebs B, Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:9846879
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