1bt7
From Proteopedia
(New page: 200px<br /> <applet load="1bt7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bt7" /> '''THE SOLUTION NMR STRUCTURE OF THE N-TERMINA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BT7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1BT7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: CTS and ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BT7 OCA]]. |
==Reference== | ==Reference== | ||
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism., Barbato G, Cicero DO, Nardi MC, Steinkuhler C, Cortese R, De Francesco R, Bazzo R, J Mol Biol. 1999 Jun 4;289(2):371-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10366511 10366511] | The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism., Barbato G, Cicero DO, Nardi MC, Steinkuhler C, Cortese R, De Francesco R, Bazzo R, J Mol Biol. 1999 Jun 4;289(2):371-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10366511 10366511] | ||
| - | [[Category: | + | [[Category: Gb virus c]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barbato, G.]] | [[Category: Barbato, G.]] | ||
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[[Category: viral non-structural protein]] | [[Category: viral non-structural protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:24:04 2007'' |
Revision as of 12:19, 30 October 2007
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THE SOLUTION NMR STRUCTURE OF THE N-TERMINAL PROTEASE DOMAIN OF THE HEPATITIS C VIRUS (HCV) NS3-PROTEIN, FROM BK STRAIN, 20 STRUCTURES
Overview
The solution structure of the hepatitis C virus (BK strain) NS3 protein, N-terminal domain (186 residues) has been solved by NMR spectroscopy. The, protein is a serine protease with a chymotrypsin-type fold, and is, involved in the maturation of the viral polyprotein. Despite the knowledge, that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the, folding in solution and the differences from the crystallographic, structures allow the formulation of a model in which, in addition to the, NS4A cofactor, the substrate plays an important role in the activation of, the catalytic mechanism. A unique structural feature is the presence of a, zinc-binding site exposed on the surface, subject to a slow ... [(full description)]
About this Structure
1BT7 is a [Single protein] structure of sequence from [Gb virus c] with ZN as [ligand]. Structure known Active Sites: CTS and ZNB. Full crystallographic information is available from [OCA].
Reference
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism., Barbato G, Cicero DO, Nardi MC, Steinkuhler C, Cortese R, De Francesco R, Bazzo R, J Mol Biol. 1999 Jun 4;289(2):371-84. PMID:10366511
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