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Ribonuclease

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[[Image:1rta.png|left|200px|thumb|Crystal Structure of Ribonuclease [[1rta]]]]
[[Image:1rta.png|left|200px|thumb|Crystal Structure of Ribonuclease [[1rta]]]]
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'''Ribonuclease''' (RNase) degrades RNA. The endonucleases cleave single or double stranded RNA and include RNase III, A, T1 H and P. Exo-RNases remove terminal nucleotide<br /> from the ends of the RNA molecule. They include RNase II D, T, PH, Polynucleotide Phosphorylase (PNPase) and oligoribonuclease (ORNase).
 RNase A cleaves C or U of single-stranded RNA (ssRNA). RNase BA is RNase from Bacillus amyloliquefaciens. RNase D degrades 3'-end pre-tRNA. RNase H cleaves RNA/DNA double-strand to produce ssDNA. RNase I cleaves 3'-end of ssRNA. RNase II degrades 3'-end ssRNA. RNase III cleaves rRNA. RNase P is a ribozyme. RNase S is RNase A cleaved by subtilisin. RNase SA is RNase from Streptomyces auerofaciens. RNase T is involved in RNA maturation. RNase T1 cleaves 3'-end G from ssRNA. RNase U2 cleaves 3'-end A from ssRNA. For more details on RNase A see:<br />
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'''Ribonuclease''' (RNase) degrades RNA. The endonucleases cleave single or double stranded RNA and include RNase III, A, T1 H and P. Exo-RNases remove terminal nucleotide<br /> from the ends of the RNA molecule. They include RNase II D, T, PH, Polynucleotide Phosphorylase (PNPase) and oligoribonuclease (ORNase).
 RNase A cleaves C or U of single-stranded RNA (ssRNA). RNase BA is RNase from Bacillus amyloliquefaciens. RNase D degrades 3'-end pre-tRNA. RNase H cleaves RNA/DNA double-strand to produce ssDNA. RNase I cleaves 3'-end of ssRNA. RNase II degrades 3'-end ssRNA. RNase III cleaves rRNA. RNase 5 is known as angiogenin and is a potent stimulator of new blood vessels formation. RNase P is a ribozyme. RNase S is RNase A cleaved by subtilisin. RNase SA is RNase from Streptomyces auerofaciens. RNase T is involved in RNA maturation. RNase T1 cleaves 3'-end G from ssRNA. RNase U2 cleaves 3'-end A from ssRNA. For more details on RNase A see:<br />
<br />
<br />
*[[RNase A]] <br />
*[[RNase A]] <br />
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[[2k11]] - hRNase I pancreatic - NMR<br />

[[2k11]] - hRNase I pancreatic - NMR<br />

[[1z7x]] - hRNase I + inhibitor
<br />
[[1z7x]] - hRNase I + inhibitor
<br />
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[[3ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I – Zebrafish<br />
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[[3ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I – Zebra fish<br />
[[2pqx]], [[2pqy]] - EcRNase I
 - ''Escherichia coli''<br />
[[2pqx]], [[2pqy]] - EcRNase I
 - ''Escherichia coli''<br />
[[2z70]], [[2ea1]] - EcRNAse I + DNA<BR />

[[2z70]], [[2ea1]] - EcRNAse I + DNA<BR />

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===RNase 5===
===RNase 5===
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[[1un3]], [[1un4]], [[1un5]], [[1gv7]] - hRNase 5 (mutant)
<br />
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[[1un3]], [[1un4]], [[1un5]], [[1gv7]], [[1b1e]], [[1b1j]], [[1k59]], [[1k5a]], [[1k5b]]]] - hRNase 5 (mutant)
<br />
 +
[[1ang]], [[1b1i]], [[2ang]] - hRNase 5 <br />
 +
[[1awz]] - hRNase 5 - NMR <br />
 +
[[1a4y]] - hRNase 5 + RNAse inhibitor
 +
[[1agi]] - bRNase 5<br />
 +
[[1h53]], [[1hby]] - hRNase 5 + phosphate derivative<br />
 +
[[1gio]] - bRNase 5 - NMR <br />
 +
[[1h53]] - hRNase 5 + PO4< br / >
[[1h0d]] - hRNase 5 + antibody<br />
[[1h0d]] - hRNase 5 + antibody<br />
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[[3lje]] - ZeRNase 5
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[[3lje]] - ZeRNase 5<br />
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[[2bwk]] - mRNase 5 + sulfate - mouse <br />
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[[2bwl]] - mRNase 5 + phosphate<br />
 +
[[2j4t]] - mRNase 5
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===RNase 6===
===RNase 6===

Revision as of 21:58, 27 August 2012

Ribonuclease A complex with thymidilic acid tetramer, 1rta

Drag the structure with the mouse to rotate

References

  1. ↑ Birdsall DL, McPherson A. Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A. J Biol Chem. 1992 Nov 5;267(31):22230-6. PMID:1429575
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