1jc9
From Proteopedia
(New page: 200px<br /><applet load="1jc9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jc9, resolution 2.01Å" /> '''TACHYLECTIN 5A FROM ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1jc9.jpg|left|200px]]<br /><applet load="1jc9" size=" | + | [[Image:1jc9.jpg|left|200px]]<br /><applet load="1jc9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jc9, resolution 2.01Å" /> | caption="1jc9, resolution 2.01Å" /> | ||
'''TACHYLECTIN 5A FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)'''<br /> | '''TACHYLECTIN 5A FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Because invertebrates lack an adaptive immune system, they had to evolve | + | Because invertebrates lack an adaptive immune system, they had to evolve effective intrinsic defense strategies against a variety of microbial pathogens. This ancient form of host defense, the innate immunity, is present in all multicellular organisms including humans. The innate immune system of the Japanese horseshoe crab Tachypleus tridentatus, serving as a model organism, includes a hemolymph coagulation system, which participates both in defense against microbes and in hemostasis. Early work on the evolution of vertebrate fibrinogen suggested a common origin of the arthropod hemolymph coagulation and the vertebrate blood coagulation systems. However, this conjecture could not be verified by comparing the structures of coagulogen, the clotting protein of the horseshoe crab, and of mammalian fibrinogen. Here we report the crystal structure of tachylectin 5A (TL5A), a nonself-recognizing lectin from the hemolymph plasma of T. tridentatus. TL5A shares not only a common fold but also related functional sites with the gamma fragment of mammalian fibrinogen. Our observations provide the first structural evidence of a common ancestor for the innate immunity and the blood coagulation systems. |
==About this Structure== | ==About this Structure== | ||
| - | 1JC9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus] with NAG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1JC9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JC9 OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tachypleus tridentatus]] | [[Category: Tachypleus tridentatus]] | ||
| - | [[Category: Beisel, H | + | [[Category: Beisel, H G.]] |
[[Category: Bode, W.]] | [[Category: Bode, W.]] | ||
[[Category: Fuentes-Prior, P.]] | [[Category: Fuentes-Prior, P.]] | ||
| Line 27: | Line 27: | ||
[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:21:03 2008'' |
Revision as of 11:21, 21 February 2008
|
TACHYLECTIN 5A FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHOE CRAB)
Overview
Because invertebrates lack an adaptive immune system, they had to evolve effective intrinsic defense strategies against a variety of microbial pathogens. This ancient form of host defense, the innate immunity, is present in all multicellular organisms including humans. The innate immune system of the Japanese horseshoe crab Tachypleus tridentatus, serving as a model organism, includes a hemolymph coagulation system, which participates both in defense against microbes and in hemostasis. Early work on the evolution of vertebrate fibrinogen suggested a common origin of the arthropod hemolymph coagulation and the vertebrate blood coagulation systems. However, this conjecture could not be verified by comparing the structures of coagulogen, the clotting protein of the horseshoe crab, and of mammalian fibrinogen. Here we report the crystal structure of tachylectin 5A (TL5A), a nonself-recognizing lectin from the hemolymph plasma of T. tridentatus. TL5A shares not only a common fold but also related functional sites with the gamma fragment of mammalian fibrinogen. Our observations provide the first structural evidence of a common ancestor for the innate immunity and the blood coagulation systems.
About this Structure
1JC9 is a Single protein structure of sequence from Tachypleus tridentatus with and as ligands. Full crystallographic information is available from OCA.
Reference
The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems., Kairies N, Beisel HG, Fuentes-Prior P, Tsuda R, Muta T, Iwanaga S, Bode W, Huber R, Kawabata S, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13519-24. Epub 2001 Nov 13. PMID:11707569
Page seeded by OCA on Thu Feb 21 13:21:03 2008
Categories: Single protein | Tachypleus tridentatus | Beisel, H G. | Bode, W. | Fuentes-Prior, P. | Huber, R. | Iwanaga, S. | Kairies, N. | Kawabata, S. | Muta, T. | Tsuda, R. | CA | NAG | Fibrinogen related | Lectin
