1jgs
From Proteopedia
(New page: 200px<br /><applet load="1jgs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jgs, resolution 2.3Å" /> '''Multiple Antibiotic R...) |
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| - | [[Image:1jgs.jpg|left|200px]]<br /><applet load="1jgs" size=" | + | [[Image:1jgs.jpg|left|200px]]<br /><applet load="1jgs" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jgs, resolution 2.3Å" /> | caption="1jgs, resolution 2.3Å" /> | ||
'''Multiple Antibiotic Resistance Repressor, MarR'''<br /> | '''Multiple Antibiotic Resistance Repressor, MarR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | MarR is a regulator of multiple antibiotic resistance in Escherichia coli. | + | MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. |
==About this Structure== | ==About this Structure== | ||
| - | 1JGS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SAL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JGS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SAL:'>SAL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Alekshun, M | + | [[Category: Alekshun, M N.]] |
| - | [[Category: Head, J | + | [[Category: Head, J F.]] |
| - | [[Category: Levy, S | + | [[Category: Levy, S B.]] |
| - | [[Category: Mealy, T | + | [[Category: Mealy, T R.]] |
| - | [[Category: Seaton, B | + | [[Category: Seaton, B A.]] |
[[Category: SAL]] | [[Category: SAL]] | ||
[[Category: antibiotic resistance]] | [[Category: antibiotic resistance]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:27 2008'' |
Revision as of 11:22, 21 February 2008
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Multiple Antibiotic Resistance Repressor, MarR
Overview
MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
About this Structure
1JGS is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:11473263
Page seeded by OCA on Thu Feb 21 13:22:27 2008
