4ehz
From Proteopedia
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{{STRUCTURE_4ehz| PDB=4ehz | SCENE= }} | {{STRUCTURE_4ehz| PDB=4ehz | SCENE= }} | ||
Revision as of 05:38, 29 August 2012
The Jak1 kinase domain in complex with inhibitor
Template:ABSTRACT PUBMED 22698084
About this Structure
4ehz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, Hanan EJ, Harstad E, Hewitt PR, Hurley CA, Jin T, Johnson A, Johnson T, Kenny JR, Koehler MF, Bir Kohli P, Kulagowski JJ, Labadie S, Liao J, Liimatta M, Lin Z, Lupardus PJ, Maxey RJ, Murray JM, Pulk R, Rodriguez M, Savage S, Shia S, Steffek M, Ubhayakar S, Ultsch M, van Abbema A, Ward SI, Xiao L, Xiao Y. Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2. J Med Chem. 2012 Jun 28. PMID:22698084 doi:10.1021/jm300628c
