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Sandbox 37

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='''Interferon-β'''=
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===Introduction===
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Interferon-β is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.<ref name="Biochem Text">Voet, D., Voet, J.G., and C. Pratt. ''Fundamentals of Biochemistry'' 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.</ref>
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===History===
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==Structure==
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<Structure load='1IFA' size='400' frame='true' align='center' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/4' />
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Interferon-β is a relatively simple biological response modifier, with several <scene name='Sandbox_37/Interferon_beta/2'>identifiable regions</scene>. It consists of five <scene name='Sandbox_37/Ifnb_helices_in_color/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Sandbox_37/Ifnb_loopregions_in_color/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.
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<ref name="Structure">PMID:20616576</ref>
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<ref name="UniProt">http://www.uniprot.org/uniprot/P00784</ref>
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===Solvent Interactions===
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===Mechanism===
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==Inhibition==
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===Inhibitors of Interferon-β===
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===Interferon-β as an Inhibitor===
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==Function==
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===Biochemical===
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===Immunological===
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==References==
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<references />
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Revision as of 02:03, 5 September 2012

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.


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