1jkw
From Proteopedia
(New page: 200px<br /> <applet load="1jkw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jkw, resolution 2.6Å" /> '''STRUCTURE OF CYCLIN ...) |
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| - | [[Image:1jkw.gif|left|200px]]<br /> | + | [[Image:1jkw.gif|left|200px]]<br /><applet load="1jkw" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1jkw" size=" | + | |
caption="1jkw, resolution 2.6Å" /> | caption="1jkw, resolution 2.6Å" /> | ||
'''STRUCTURE OF CYCLIN MCS2'''<br /> | '''STRUCTURE OF CYCLIN MCS2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of human cyclin H has been solved at 2.6 A | + | The crystal structure of human cyclin H has been solved at 2.6 A resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule. |
==About this Structure== | ==About this Structure== | ||
| - | 1JKW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1JKW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Moras, D.]] | [[Category: Moras, D.]] | ||
[[Category: Poterszman, A.]] | [[Category: Poterszman, A.]] | ||
| - | [[Category: Thierry, J | + | [[Category: Thierry, J C.]] |
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
[[Category: cell division]] | [[Category: cell division]] | ||
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[[Category: nuclear protein]] | [[Category: nuclear protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:46 2008'' |
Revision as of 11:23, 21 February 2008
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STRUCTURE OF CYCLIN MCS2
Overview
The crystal structure of human cyclin H has been solved at 2.6 A resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule.
About this Structure
1JKW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human cyclin H., Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC, FEBS Lett. 1996 Nov 11;397(1):65-9. PMID:8941715
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