1jmm
From Proteopedia
(New page: 200px<br /><applet load="1jmm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jmm, resolution 2.40Å" /> '''Crystal structure of...) |
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| - | [[Image:1jmm.jpg|left|200px]]<br /><applet load="1jmm" size=" | + | [[Image:1jmm.jpg|left|200px]]<br /><applet load="1jmm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jmm, resolution 2.40Å" /> | caption="1jmm, resolution 2.40Å" /> | ||
'''Crystal structure of the V-region of Streptococcus mutans antigen I/II'''<br /> | '''Crystal structure of the V-region of Streptococcus mutans antigen I/II'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Antigens I/II are large multifunctional adhesins from oral viridans | + | Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant protein and subsequently refined at 2.4 A resolution. The crystal structure of SrV+ revealed a lectin-like fold that displays a putative preformed carbohydrate-binding site stabilized by a metal ion. Inhibition of this binding site may confer to humans a protection against dental caries and dissemination of the bacteria to extra-oral sites involved in life-threatening inflammatory diseases. This crystal structure constitutes a first step in understanding the structure-function relationship of antigens I/II and may help in delineating new preventive or therapeutic strategies against colonization of the host by oral streptococci. |
==About this Structure== | ==About this Structure== | ||
| - | 1JMM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JMM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: v-region]] | [[Category: v-region]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:18 2008'' |
Revision as of 11:24, 21 February 2008
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Crystal structure of the V-region of Streptococcus mutans antigen I/II
Overview
Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant protein and subsequently refined at 2.4 A resolution. The crystal structure of SrV+ revealed a lectin-like fold that displays a putative preformed carbohydrate-binding site stabilized by a metal ion. Inhibition of this binding site may confer to humans a protection against dental caries and dissemination of the bacteria to extra-oral sites involved in life-threatening inflammatory diseases. This crystal structure constitutes a first step in understanding the structure-function relationship of antigens I/II and may help in delineating new preventive or therapeutic strategies against colonization of the host by oral streptococci.
About this Structure
1JMM is a Single protein structure of sequence from Streptococcus mutans with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:12054777
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