1jnp
From Proteopedia
(New page: 200px<br /><applet load="1jnp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jnp, resolution 2.50Å" /> '''Crystal Structure of...) |
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| - | [[Image:1jnp.jpg|left|200px]]<br /><applet load="1jnp" size=" | + | [[Image:1jnp.jpg|left|200px]]<br /><applet load="1jnp" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jnp, resolution 2.50Å" /> | caption="1jnp, resolution 2.50Å" /> | ||
'''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''<br /> | '''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell | + | Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions. |
==About this Structure== | ==About this Structure== | ||
| - | 1JNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1JNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Croce, C | + | [[Category: Croce, C M.]] |
| - | [[Category: DuBois, G | + | [[Category: DuBois, G C.]] |
| - | [[Category: Harrison, R | + | [[Category: Harrison, R W.]] |
| - | [[Category: Petock, J | + | [[Category: Petock, J M.]] |
| - | [[Category: Torshin, I | + | [[Category: Torshin, I Y.]] |
| - | [[Category: Wang, Y | + | [[Category: Wang, Y F.]] |
| - | [[Category: Weber, I | + | [[Category: Weber, I T.]] |
[[Category: beta barrel]] | [[Category: beta barrel]] | ||
[[Category: dimer]] | [[Category: dimer]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:37 2008'' |
Revision as of 11:24, 21 February 2008
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Crystal Structure of Murine Tcl1 at 2.5 Resolution
Overview
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
About this Structure
1JNP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718
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