Argonaute

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Revision as of 08:39, 6 September 2012

The Argonaute family of proteins is central to the RNA-induced silencing in eukaryotic organisms [1]. It was first found to be important for plant development and for germline stem-cell division in Drosophila Melanogaster, but further research revealed a much broader and essential role in protein synthesis, maintenance of genome integrity and RNA stability [2].

Structure of human Argonaute2 protein in complex with target RNA (PDB Entry 4EI1)

Drag the structure with the mouse to rotate

Contents

The Argonaute Family

Role in RNA interference

Members

Structure

N Domain

Paz Domain

Mid Domain

Piwi Domain

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, João Rodrigues, Joel L. Sussman, Alexander Berchansky

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