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Revision as of 08:59, 6 September 2012

Usage of bovine aconitase as a template for homology modelling of yeast aconitase

spinqualitylabelsall models Structure bovine aconitase(PDB entry 1aco) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Aconitase is an enzyme participating in the citric acid cycle. It is highly conserved among many species. It has been shown [1] that it is dually located in mitochondria and the cytosol by means of reverse translocation. To understand the underlying mechanism that enables this phenomena, a structural predicted model has been created using the I-TASSER homology modelling server [2]

1. ↑ Regev-Rudzki N, Karniely S, Ben-Haim NN, Pines O. Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol Biol Cell. 2005 Sep;16(9):4163-71. Epub 2005 Jun 22. PMID:15975908 doi:10.1091/mbc.E04-11-1028
2. ↑ Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics. 2008 Jan 23;9:40. PMID:18215316 doi:10.1186/1471-2105-9-40