Sandbox or
From Proteopedia
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<StructureSection load='3se3' size='350' side='right' caption='Structure of interferon YNS ternary complex(PDB entry [[3se3]])' scene=''> | <StructureSection load='3se3' size='350' side='right' caption='Structure of interferon YNS ternary complex(PDB entry [[3se3]])' scene=''> | ||
Anything in this section will appear adjacent to the 3D structure and will be scrollable. | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
| - | ifn-YNS <scene name='Sandbox_or/Yns/1'>(YNS)</scene> is an interferon alpha 2 mutant with improved affinity to interferon alpha receptor 1 (IFNAR1). it contains three mutations on the interface of the binding site: | + | ifn-YNS <scene name='Sandbox_or/Yns/1'>(YNS)</scene> is an interferon alpha 2 mutant with improved affinity to interferon alpha receptor 1 (IFNAR1). it contains three mutations on the interface of the binding site: <scene name='Sandbox_or/Yns_mutations/2'>H57Y, E58N and Q61S</scene>.<ref> pmid 17310065</ref> |
Revision as of 09:17, 6 September 2012
interferon YNS ternary complex
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- ↑ Kalie E, Jaitin DA, Abramovich R, Schreiber G. An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities. J Biol Chem. 2007 Apr 13;282(15):11602-11. Epub 2007 Feb 19. PMID:17310065 doi:10.1074/jbc.M610115200
