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Sandbox pia
From Proteopedia
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The model displays one half of the symmetric 26S proteasome <scene name='Sandbox_pia/26s_color/1'>26S</scene>. The complex consists of a core particle, build out of 4 heptameric rings in the order α - β - β - α (<scene name='Sandbox_pia/Cp/1'>half CP</scene>) | The model displays one half of the symmetric 26S proteasome <scene name='Sandbox_pia/26s_color/1'>26S</scene>. The complex consists of a core particle, build out of 4 heptameric rings in the order α - β - β - α (<scene name='Sandbox_pia/Cp/1'>half CP</scene>) | ||
| - | The regulatory particle is divided into a base and a lid. The base are 6 AAA-ATPases (Rpt1-6), Rpn1 whereas the lid consists of non-ATPases, some containing a PCI domain( Rpn9,5 6 73 12) or a <scene name='Sandbox_pia/Mpn/5'>MPN</scene> domain (Rpn8, 11) as well as Ubiquitin receptors (Rpn10,13) | + | The regulatory particle is divided into a base and a lid. The base are 6 AAA-ATPases (Rpt1-6), Rpn1 whereas the lid consists of non-ATPases, some containing a PCI domain( Rpn9,5 6 73 12 <scene name='Sandbox_pia/Pci/2'>PCI - containing subunits </scene>) or a <scene name='Sandbox_pia/Mpn/5'>MPN</scene> domain (Rpn8, 11) as well as Ubiquitin receptors (Rpn10,13). |
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| + | The C-termini (like the <scene name='Sandbox_pia/Rpt2_ter/2'>Rpt2 C-Terminus</scene>) of some ATPases can be localized in pockets between the alpha subunits and might play a role in gate opening, as suggested by <ref> pmid </ref>. | ||
| - | The C-termini (like the <scene name='Sandbox_pia/Rpt2_ter/2'>Rpt2 C-Terminus</scene>) of some ATPases can be localized in pockets between the alpha subunits and play a role in gate opening, as suggested by <ref> pmid </ref> | ||
Revision as of 11:27, 6 September 2012
Structural model of yeast 26S
About this Structure
4b4t is a 31 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA and described in Beck et al.[1]. Previous publications describing the architecture are [2] [3] [4]
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- ↑ Beck F, Unverdorben P, Bohn S, Schweitzer A, Pfeifer G, Sakata E, Nickell S, Plitzko JM, Villa E, Baumeister W, Forster F. Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A. 2012 Aug 27. PMID:22927375 doi:10.1073/pnas.1213333109
- ↑ Lasker K, Forster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380-7. Epub 2012 Jan 23. PMID:22307589 doi:10.1073/pnas.1120559109
- ↑ Lander GC, Estrin E, Matyskiela ME, Bashore C, Nogales E, Martin A. Complete subunit architecture of the proteasome regulatory particle. Nature. 2012 Jan 11;482(7384):186-91. doi: 10.1038/nature10774. PMID:22237024 doi:10.1038/nature10774
- ↑ Forster F, Lasker K, Nickell S, Sali A, Baumeister W. Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics. 2010 Aug;9(8):1666-77. Epub 2010 May 13. PMID:20467039 doi:10.1074/mcp.R000002-MCP201
- ↑ . PMID:216315890657
