Sandbox or
From Proteopedia
(Difference between revisions)
(→interferon YNS ternary complex) |
(→interferon YNS ternary complex) |
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ifn-YNS <scene name='Sandbox_or/Yns/1'>(YNS)</scene> is an interferon alpha 2 mutant with improved affinity to interferon alpha receptor 1 (IFNAR1). it contains three mutations on the interface of the binding site: <scene name='Sandbox_or/Yns_mutations/2'>H57Y, E58N and Q61S</scene><ref> pmid 17310065</ref>. | ifn-YNS <scene name='Sandbox_or/Yns/1'>(YNS)</scene> is an interferon alpha 2 mutant with improved affinity to interferon alpha receptor 1 (IFNAR1). it contains three mutations on the interface of the binding site: <scene name='Sandbox_or/Yns_mutations/2'>H57Y, E58N and Q61S</scene><ref> pmid 17310065</ref>. | ||
While residue 57 is shown only in ifn beta, which binds IFNAR1 in high affinities, the other two residues does not seem to have any pattern that can suggest that it creates strong binding<ref> pmid 21854986</ref>. | While residue 57 is shown only in ifn beta, which binds IFNAR1 in high affinities, the other two residues does not seem to have any pattern that can suggest that it creates strong binding<ref> pmid 21854986</ref>. | ||
| - | Using aquaprot we predict that the three residues mentioned (YNS) bind to the residues <scene name='Sandbox_or/Yns_ifnar1/6'>S135 and T181</scene> | + | Using aquaprot we predict that the three residues mentioned (YNS) bind to the residues <scene name='Sandbox_or/Yns_ifnar1/6'>S135 and T181</scene>. |
</StructureSection> | </StructureSection> | ||
<references/> | <references/> | ||
Current revision
interferon YNS ternary complex
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- ↑ Kalie E, Jaitin DA, Abramovich R, Schreiber G. An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities. J Biol Chem. 2007 Apr 13;282(15):11602-11. Epub 2007 Feb 19. PMID:17310065 doi:10.1074/jbc.M610115200
- ↑ Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC. Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons. Cell. 2011 Aug 19;146(4):621-32. PMID:21854986 doi:10.1016/j.cell.2011.06.048
