1jr4
From Proteopedia
(New page: 200px<br /><applet load="1jr4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jr4, resolution 2.63Å" /> '''CATECHOL O-METHYLTRA...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1jr4.jpg|left|200px]]<br /><applet load="1jr4" size=" | + | [[Image:1jr4.jpg|left|200px]]<br /><applet load="1jr4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jr4, resolution 2.63Å" /> | caption="1jr4, resolution 2.63Å" /> | ||
'''CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX'''<br /> | '''CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX'''<br /> | ||
==About this Structure== | ==About this Structure== | ||
| - | 1JR4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with MG and CL4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] Full crystallographic information is available from [http:// | + | 1JR4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=CL4:'>CL4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR4 OCA]. |
==Reference== | ==Reference== | ||
| Line 20: | Line 20: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:25:50 2008'' |
Revision as of 11:25, 21 February 2008
|
CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX
About this Structure
1JR4 is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Active as Catechol O-methyltransferase, with EC number 2.1.1.6 Full crystallographic information is available from OCA.
Reference
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. , Lerner C, Ruf A, Gramlich V, Masjost B, Zurcher G, Jakob-Roetne R, Borroni E, Diederich F, Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. PMID:12404486
Page seeded by OCA on Thu Feb 21 13:25:50 2008
