1jux
From Proteopedia
(New page: 200px<br /><applet load="1jux" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jux, resolution 1.6Å" /> '''1.6A Resolution Cryst...) |
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| - | [[Image:1jux.gif|left|200px]]<br /><applet load="1jux" size=" | + | [[Image:1jux.gif|left|200px]]<br /><applet load="1jux" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jux, resolution 1.6Å" /> | caption="1jux, resolution 1.6Å" /> | ||
'''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''<br /> | '''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with | + | The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin. |
==About this Structure== | ==About this Structure== | ||
| - | 1JUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DMY as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: side-by-side]] | [[Category: side-by-side]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:01 2008'' |
Revision as of 11:27, 21 February 2008
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1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side
Overview
The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.
About this Structure
1JUX is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:14646114
Page seeded by OCA on Thu Feb 21 13:27:01 2008
Categories: Protein complex | Deng, J. | Pan, B. | Sundaralingam, M. | DMY | Distamycin | Dna | Octamer | Side-by-side
