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2j8x

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(New page: 200px<br /> <applet load="2j8x" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j8x, resolution 2.30&Aring;" /> '''EPSTEIN-BARR VIRUS ...)
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==About this Structure==
==About this Structure==
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2J8X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bacteriophage_pbs2 Bacteriophage pbs2]] and [[http://en.wikipedia.org/wiki/Epstein-barr_virus Epstein-barr virus]] with URE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J8X OCA]].
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2J8X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]] and [[http://en.wikipedia.org/wiki/Phage_pbs1 Phage pbs1]] with URE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J8X OCA]].
==Reference==
==Reference==
New insights on the role of the gamma-herpesvirus uracil-DNA glycosylase leucine loop revealed by the structure of the Epstein-Barr virus enzyme in complex with an inhibitor protein., Geoui T, Buisson M, Tarbouriech N, Burmeister WP, J Mol Biol. 2007 Feb 9;366(1):117-31. Epub 2006 Nov 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17157317 17157317]
New insights on the role of the gamma-herpesvirus uracil-DNA glycosylase leucine loop revealed by the structure of the Epstein-Barr virus enzyme in complex with an inhibitor protein., Geoui T, Buisson M, Tarbouriech N, Burmeister WP, J Mol Biol. 2007 Feb 9;366(1):117-31. Epub 2006 Nov 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17157317 17157317]
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[[Category: Bacteriophage pbs2]]
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[[Category: Human herpesvirus 4]]
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[[Category: Epstein-barr virus]]
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[[Category: Phage pbs1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Uridine nucleosidase]]
[[Category: Buisson, M.]]
[[Category: Buisson, M.]]
[[Category: Burmeister, W.P.]]
[[Category: Burmeister, W.P.]]
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[[Category: uracil-dna glycosylase inhibitor]]
[[Category: uracil-dna glycosylase inhibitor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 22:03:45 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:28:23 2007''

Revision as of 12:23, 30 October 2007

Image:2j8x.gif

2j8x, resolution 2.30Å

Drag the structure with the mouse to rotate

EPSTEIN-BARR VIRUS URACIL-DNA GLYCOSYLASE IN COMPLEX WITH UGI FROM PBS-2

Overview

Epstein-Barr virus (EBV) is a human gamma-herpesvirus. Within its 86 open, reading frame containing genome, two enzymes avoiding uracil incorporation, into DNA can be found: uracil triphosphate hydrolase and uracil-DNA, glycosylase (UNG). The latter one excises uracil bases that are due to, cytosine deamination or uracil misincorporation from double-stranded DNA, substrates. The EBV enzyme belongs to family 1 UNGs. We solved the, three-dimensional structure of EBV UNG in complex with the uracil-DNA, glycosylase inhibitor protein (Ugi) from bacteriophage PBS-2 at a, resolution of 2.3 A by X-ray crystallography. The structure of EBV UNG, encoded by the BKRF3 reading frame shows the excellent global structural, conservation within the solved examples of family 1 enzymes. Four out of, the ... [(full description)]

About this Structure

2J8X is a [Protein complex] structure of sequences from [Human herpesvirus 4] and [Phage pbs1] with URE as [ligand]. Active as [Uridine nucleosidase], with EC number [3.2.2.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

New insights on the role of the gamma-herpesvirus uracil-DNA glycosylase leucine loop revealed by the structure of the Epstein-Barr virus enzyme in complex with an inhibitor protein., Geoui T, Buisson M, Tarbouriech N, Burmeister WP, J Mol Biol. 2007 Feb 9;366(1):117-31. Epub 2006 Nov 7. PMID:17157317

Page seeded by OCA on Tue Oct 30 14:28:23 2007

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