1k12
From Proteopedia
(New page: 200px<br /><applet load="1k12" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k12, resolution 1.90Å" /> '''Fucose Binding lecti...) |
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| - | [[Image:1k12.gif|left|200px]]<br /><applet load="1k12" size=" | + | [[Image:1k12.gif|left|200px]]<br /><applet load="1k12" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1k12, resolution 1.90Å" /> | caption="1k12, resolution 1.90Å" /> | ||
'''Fucose Binding lectin'''<br /> | '''Fucose Binding lectin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of | + | Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition. |
==About this Structure== | ==About this Structure== | ||
| - | 1K12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla] with FUC, CA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1K12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Anguilla_anguilla Anguilla anguilla] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K12 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Anguilla anguilla]] | [[Category: Anguilla anguilla]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Amzel, L | + | [[Category: Amzel, L M.]] |
| - | [[Category: Bianchet, M | + | [[Category: Bianchet, M A.]] |
| - | [[Category: Odom, E | + | [[Category: Odom, E W.]] |
| - | [[Category: Vasta, G | + | [[Category: Vasta, G R.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: protein carbohydrate complex]] | [[Category: protein carbohydrate complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:28:56 2008'' |
Revision as of 11:28, 21 February 2008
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Fucose Binding lectin
Overview
Anguilla anguilla agglutinin (AAA), a fucolectin found in the serum of European eel, participates in the recognition of bacterial liposaccharides by the animal innate immunity system. Because AAA specifically recognizes fucosylated terminals of H and Lewis (a) blood groups, it has been used extensively as a reagent in blood typing and histochemistry. AAA contains a newly discovered carbohydrate recognition domain present in proteins of organisms ranging from bacteria to vertebrates. The crystal structure of the complex of AAA with alpha-L-fucose characterizes the novel fold of this entire lectin family, identifying the residues that provide the structural determinants of oligosaccharide specificity. Modification of these residues explains how the different isoforms in serum can provide a diverse pathogen-specific recognition.
About this Structure
1K12 is a Single protein structure of sequence from Anguilla anguilla with , and as ligands. Full crystallographic information is available from OCA.
Reference
A novel fucose recognition fold involved in innate immunity., Bianchet MA, Odom EW, Vasta GR, Amzel LM, Nat Struct Biol. 2002 Aug;9(8):628-34. PMID:12091873
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