Sandbox reserved CDK2 Oxindole Inhibitor
From Proteopedia
(Difference between revisions)
(New page: == Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor == <StructureSection load='1dq8' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8...) |
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== Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor == | == Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor == | ||
| - | <StructureSection load=' | + | <StructureSection load='1fvt' size='350' side='left' caption='Structure of CDK2 with 4-(5-bromo-2-oxo-2h-indol-3-ylazo)-benzenesulfonamide (PDB entry [[1fvt]])' scene=''> |
| - | + | *The representation displayed is that of cyclin-dependent kinase 2 (CDK2) as the protein. The ligand pictured is the oxindole inhibitor, 4-(5-bromo-2-oxo-2h-indol-3-ylazo)- benzenesulfonamide. CDK2 is part of the Ser/Thr protein kinases. CDK2 is a positive regulator of the eukaryotic cell cycle progression and is a catalytic unit that helps the cell progress from G1 to S. | |
| - | + | *In the study “The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor” researchers studied whether using a topical oxindole inhibitor would reduce the chemotherapy-induced alopecia (CIA). Alopecia is characterized by hair loss. By inhibiting the CDK2, the cell cycle is slowed and the sensitivity to the epithelium from many cell cycle-active antitumor agents is reduced. | |
| - | </ | + | *The CDK2 is composed of a total of 7 alpha-helices and 6 beta-sheets. The <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Secondary_structures/1'>alpha-helices and beta-sheets</scene> can be seen here. |
| + | *This presentation of the protein-ligand module shows the <scene name='Sandbox_reserved_CDK2_Oxindole_Inhibitor/Active_site/1'>active site</scene> in which the oxindole inhibitor interacts with CDK2. The oxindole inhibitor interacts with CDK2 throught the Asp86A, ILe10A, Phe80A, and Leu83A amino acids on CDK2 | ||
Revision as of 17:43, 19 September 2012
Cyclin-Dependend Kinase 2 (CDK2) in Complex with an Oxindole Inhibitor
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