Fragment-Based Drug Discovery

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Shown here is the interaction between paclitaxel and the protein via <scene name='Sandbox_reserved_394/Hydrogen_bonds/4'>hydrogen bonding</scene>. The hydrogen bond is formed between an oxygen (red) from the sulfoxone portion of the drug to an "N-H" group (grey) of a glycine amino acid.
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Shown here is the interaction between paclitaxel and the protein via <scene name='Sandbox_reserved_394/Hydrogen_bonds/7'>hydrogen bond</scene>. The hydrogen bond is formed between an oxygen (red) from the sulfoxone portion of the drug to an "N-H" group (grey) of a glycine amino acid (blue).
Shown here is the <scene name='Sandbox_reserved_394/Hydrophobic_bonding/3'>hydrophobic bonding</scene> formed between the protein (grey) and a hydrophobic portion of paclitaxel (blue).
Shown here is the <scene name='Sandbox_reserved_394/Hydrophobic_bonding/3'>hydrophobic bonding</scene> formed between the protein (grey) and a hydrophobic portion of paclitaxel (blue).
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</StructureSection>

Revision as of 18:45, 19 September 2012

== Paclitaxel in Apoptosis ==

Structure of HMG-CoA reductase (PDB entry 1ysi)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Justin Weekley, Arthur Cox, Jaime Prilusky

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