This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1k3k
From Proteopedia
(New page: 200px<br /><applet load="1k3k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k3k" /> '''Solution Structure of a Bcl-2 Homolog from K...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1k3k.gif|left|200px]]<br /><applet load="1k3k" size=" | + | [[Image:1k3k.gif|left|200px]]<br /><applet load="1k3k" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1k3k" /> | caption="1k3k" /> | ||
'''Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus'''<br /> | '''Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has | + | Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1K3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http:// | + | 1K3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Fesik, S | + | [[Category: Fesik, S W.]] |
[[Category: Huang, Q.]] | [[Category: Huang, Q.]] | ||
| - | [[Category: Olejniczak, E | + | [[Category: Olejniczak, E T.]] |
| - | [[Category: Petros, A | + | [[Category: Petros, A M.]] |
| - | [[Category: Virgin, H | + | [[Category: Virgin, H W.]] |
[[Category: bcl-2]] | [[Category: bcl-2]] | ||
[[Category: herpesvirus]] | [[Category: herpesvirus]] | ||
| Line 23: | Line 23: | ||
[[Category: solution structure]] | [[Category: solution structure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:29:45 2008'' |
Revision as of 11:29, 21 February 2008
|
Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus
Overview
Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
About this Structure
1K3K is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405
Page seeded by OCA on Thu Feb 21 13:29:45 2008
