1bn5
From Proteopedia
(New page: 200px<br /> <applet load="1bn5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn5, resolution 1.8Å" /> '''HUMAN METHIONINE AMI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BN5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CO and TBU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN5 OCA]]. | + | 1BN5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CO and TBU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18]]. Structure known Active Site: CO2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN5 OCA]]. |
==Reference== | ==Reference== | ||
Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9812898 9812898] | Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9812898 9812898] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Methionyl aminopeptidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clardy, J.C.]] | [[Category: Clardy, J.C.]] | ||
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[[Category: methionine aminopeptidase]] | [[Category: methionine aminopeptidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:29:08 2007'' |
Revision as of 12:24, 30 October 2007
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HUMAN METHIONINE AMINOPEPTIDASE 2
Overview
The fungal metabolite fumagillin suppresses the formation of new blood, vessels, and a fumagillin analog is currently in clinical trials as an, anticancer agent. The molecular target of fumagillin is methionine, aminopeptidase-2 (MetAP-2). A 1.8 A resolution crystal structure of free, and inhibited human MetAP-2 shows a covalent bond formed between a, reactive epoxide of fumagillin and histidine-231 in the active site of, MetAP-2. Extensive hydrophobic and water-mediated polar interactions with, other parts of fumagillin provide additional affinity. Fumagillin-based, drugs inhibit MetAP-2 but not MetAP-1, and the three-dimensional structure, also indicates the likely determinants of this specificity. The structural, basis for fumagillin's potency and specificity forms the starting point, ... [(full description)]
About this Structure
1BN5 is a [Single protein] structure of sequence from [Homo sapiens] with CO and TBU as [ligands]. Active as [Methionyl aminopeptidase], with EC number [3.4.11.18]. Structure known Active Site: CO2. Full crystallographic information is available from [OCA].
Reference
Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:9812898
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