1k8i
From Proteopedia
(New page: 200px<br /><applet load="1k8i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k8i, resolution 3.10Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1k8i.jpg|left|200px]]<br /><applet load="1k8i" size=" | + | [[Image:1k8i.jpg|left|200px]]<br /><applet load="1k8i" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1k8i, resolution 3.10Å" /> | caption="1k8i, resolution 3.10Å" /> | ||
'''CRYSTAL STRUCTURE OF MOUSE H2-DM'''<br /> | '''CRYSTAL STRUCTURE OF MOUSE H2-DM'''<br /> | ||
==Overview== | ==Overview== | ||
| - | H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where | + | H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor. |
==About this Structure== | ==About this Structure== | ||
| - | 1K8I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1K8I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8I OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Crawford, F.]] | [[Category: Crawford, F.]] | ||
| - | [[Category: Fremont, D | + | [[Category: Fremont, D H.]] |
[[Category: Hendrickson, W.]] | [[Category: Hendrickson, W.]] | ||
[[Category: Kappler, J.]] | [[Category: Kappler, J.]] | ||
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[[Category: mhc]] | [[Category: mhc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:14 2008'' |
Revision as of 11:31, 21 February 2008
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CRYSTAL STRUCTURE OF MOUSE H2-DM
Overview
H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.
About this Structure
1K8I is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758
Page seeded by OCA on Thu Feb 21 13:31:14 2008
